Clin Pharmacokinet 2008; 47 (3): 173-180
نویسندگان
چکیده
Patients and methods: A prospective, open-label study was conducted in 20 patients undergoing CRRT. Blood and dialysate-ultrafiltrate samples were obtained after administration of 500 mg, 1000 mg or 2000 mg of meropenem every 6 or 8 hours by intravenous infusion. The data were analysed under the population approach using NONMEM version V software. Age, bodyweight, dialysate plus ultrafiltrate flow, creatinine clearance (CLCR), the unbound drug fraction in plasma, the type of membrane, CRRT and the patient type (whether septic or severely polytraumatized) were the covariates studied.
منابع مشابه
Clin Pharmacokinet 2008; 47 (12): 817-825
1 Centre de Référence des Maladies Héréditaires du Métabolisme, Hôpital d’Enfants, CHU Brabois, Vandoeuvre les Nancy, France 2 UBC Department of Medical Genetics, Children’s Hospital Research Institute, Vancouver, Canada 3 Azienda Ospedaliera Universitaria, Catania, Italy 4 Kaiser Permanente Medical Center, Sacramento, California, USA 5 Manchester Children’s Hospital, Manchester, UK 6 Children’...
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